Zoloft pharmacokinetics in special clinical situations
The pharmacokinetic profile in adolescents and the elderly is not significantly different from that of patients aged 18 to 65 years.
It is shown that the pharmacokinetics of Zoloft in children with OCD is similar to those in adults (although the metabolism of sertraline in children is somewhat more active). However, given the lower body mass in children (especially those aged 6-12 years), a drug is recommended for use in smaller dose to avoid excessive levels in plasma.
In patients with liver cirrhosis the T1 / 2 and AUC level of the drug increases, compared with those in healthy people.
According to the pharmacokinetic study, after repeated taking of Zolft in patients with stable cirrhosis of easy flow, an increase in T1 / 2 of the drug and almost three-fold increase in AUC (area under the curve of the concentration / time) and Cmax of the drug compared with those in healthy people. There were no significant differences in the binding to plasma proteins in 2 groups.
In patients with mild and moderate renal impairment (creatinine clearance 30-60 ml / min) and patients with moderate or severe renal impairment (creatinine clearance 10-29 ml / min), the pharmacokinetic parameters (AUC0-24 and Cmax) of Zoloft with repeated its admission not significantly different from controls. In all groups, T1 / 2 of the drug was the same as there were no differences in the binding to plasma proteins.
Zoloft is prescribed medication, which you will be able to buy at pharmacies only after doctor’s consultation. But you can also buy Zoloft online, where you don’t need any prescriptions.